Celiac disease can be caused by a usually harmless virus
Celiac disease is an as yet incurable disease characterized by gluten intolerance, which The use of the patch was painless, he said. Until now, this immune disease was thought to have a genetic basis, but new research suggests that a virus may be responsible for it. Currently, the only treatment is a lifelong strict diet.
New light has been shed on this disease by American scientists. The study was conducted on mice, which re as a result of genetic modifications have become more predisposed to celiac disease. Researchers noted that those who re were infected with reoviruses were significantly more likely to have an immune system response against gluten. The observed immune system response is very similar to that of those who The band can be seen in os b celiac disease patients.
Reoviruses are widely distributed viruses worldwide. According to estimates In, about 70% of. Children under the age of five have antibodies against them. Their family consists of at least nine genera. For human pathotw The main viruses are orbiviruses, rotaviruses and coltiviruses. Cause diarrheal and febrile illnesses.
During the study of celiac disease, a higher number of antibodies to reoviruses were found in por in relation to os b unaffected by the disease. This may suggest the validity of the thesis of the scientistsc of the University of Chicago Celiac Disease Center. Their findings suggest that reovirus infection can leave a permanent mark on the immune system, which in turn can lead to celiac disease.
– Although the virus does not give signs, it can affect the body’s immune system, causing it to be disrupted – said co routor of research by Dr. Ban Jabri.
In addition to that found in wasps b affected by celiac disease with an elevated number of antibodies to reoviruses, the researchers also found increased expression of a gene that ry encode a protein called IRF1. During studies on mice, it was observed that it was the IRF1 protein that played a significant role in the development of gluten intolerance after infection with reovirus.
The researchers noted that only one strain of reovirus called T1L elicited the immune response observed in the study. The second strain, which ry was tested during the study called T3D, ry is genetically different from T1L and did not induce an immune response. It is not clear how the other strains behave.
The toxic effect of gluten in wasps b with celiac disease leads to the disappearance of villi in the small intestine. The results of the study by American scientists showed that infection with the reovirus led to an immune response against gluten, but the response itself would not damage the small intestine. Therefore, the researchers do not exclude other factors In causing the disease, such as genetic predisposition or og lny condition.