American scientists cured diabetes in mice
Texas scientists have developed an effective therapy against diabetes. It has successfully cured a laboratory mouse of type 1 diabetes. But researchers say the new technique will also find application in type 2 diabetes.
A potential cure for diabetes is on the horizon. A new technique developed at the University of Texas Health San Antonio increases the number of com rek in the pancreas, which re produce insulin. Thanks to it, a lab mouse was cured of type 1 diabetes. Researchers hope to begin human trials within the next three years.
– Our method works perfectly. We cured a mouse of type 1 diabetes and observed no effect for a year in side. A similar condition has never been achieved before. However, our technique was applied in mice, so caution should be exercised. Currently, we want to use the method on large animals, kt re are closer to humans in terms of physiology and endocrine system – said Dr. Bruno Doiron, co routor of research.
Diabetes is a disease characterized by elevated blood glucose levels. It is caused by a defect in the work of the com rec beta pancreas, which re produce insulin. – The pancreas has many more type in rek outside the com beta. Our method is to change these com rek so that they begin to secrete insulin, but only in response to glucose – explained Ralph DeFronzo, kt ry was also involved in the research.
Insulin, which ra lowers blood sugar, is produced only by the com rki beta. In type 1 diabetes com Beta cells are destroyed by the immune system. Subsequently, the ability to produce insulin disappears. In type 2 diabetes, tissue sensitivity to insulin is reduced. By this, the body demands increased insulin production, which exceeds the capacity of the com beta sharks. As a result, com beta cells do not function properly and insulin levels in the body decrease, although it is still produced. Type 2 diabetes is the most common form of diabetes.
The therapy developed by the Texas scientists uses the technique of transferring gene. A virus (inactive) is used as a vector or carrier, which ry introduces selected genes into the pancreas. These genes become activated stimulate digestive enzymes and other types of com rek (in addition to the beta cells) to produce insulin.
This therapy precisely regulates blood sugar levels in mice. It’s a big step forward d at the por In comparison with traditional insulin therapy and some rymi antidiabetic drugs, which re cause blood sugar levels to drop if not monitored closely.
This method is able to pom c also in type 2 diabetes. Thanks to gene transfer in the body will produce adequate levels of insulin, although it will not be produced by the com rki beta.