Trained lymphocytes will fight cancer?

Modifying lymphocytes isolated from dogs so that they are able to defeat cancer cells without harming healthy cells is the goal of the research led by Dr. Kinga Majchrzak of the Warsaw University of Life Sciences.

On her j research project, Dr. Kinga Majchrzak has just received nearly PLN 2 million from the Foundation for Polish Science.

This is a continuation of research conducted by Dr. Kinga Majchrzak during her two-year internship, which ry she held at the Medical University of South Carolina (USA). At this center, the team ł from immuno-oncology is conducting research under the direction of Dr. Chrystal Paulos on the use of lymphocytes in T in m melanoma and pancreatic cancer – dw ch cancer In extremely resistant to commonly used cancer therapies. Dr. Majchrzak’s work there involved modifying lymphocyte in Th17, in such a way b to be as effective as possible against melanoma. The research was conducted on mice – but successful therapy in rodents is a long way from treatment in humans.

The next phase of research will be conducted on lymphocytes isolated from ps. – Dogs suffer from similar cancers as humans, the course of the disease is almost the same in them, and the immune system functions very similarly, explains Dr. Kinga Majchrzak, quoted in a press release sent by SGGW. – For this reason, the research conducted on canine lymphocytes will have a higher cognitive value than that performed on mice, she adds.

– We plan to learn the roles of signaling pathways in melanoma infiltrating lymphocytes in ps in order to increase their anti-tumor activity, for now in the laboratory and in the future in the clinic. The results of this research will benefit the zar both for veterinary medicine and medicine,” admits the researcher. – Learning the importance of the pathway in signaling in lymphocytes will expand our knowledge of how the immune system works, but could open Also new opportunities to develop a protocol in the culture of these com rec for target in immunotherapy in humans. Animals that re will get a chance to recover,” he explains.

Dr. Majchrzak has been named the winner of the third competition organized by the Foundation for Polish Science under the First Team program. The grant of nearly PLN 2 million will allow her to set up at the School of Head The SGGW’s own research team. Sw j project called "Trail modification In signaling subpopulations of lymphocytes in Th17 on a dog model to improve adoptive immunotherapy of com rk in humans" Polish researcher will conduct in cooperation with In cooperation with Dr. Paulos from the Medical University of South Carolina. The anticipated duration of the research project is three years.