Antibiotics can hinder immune cells from functioning properly
Antibiotics help us fight off dangerous infections and are often a patient’s only salvation, but according to Broad Institute researchers, they can also reduce the ability of immune cells to destroy bacteria in the body’s.
New research by scientist from the Broad Institute (Eli and Edythe L. Broad Institute of MIT and Harvard), published in Cell Host & Microbe, they can change the way b how we use antibiotics. They also provide some indications ek how to deal with increased resistance to antibiotics some ric bacteria.
Antibiotics can sometimes kill "good" bacteria while fighting the infection. This is a previously unexplored side effect. – Antibiotics interact with the com rkami, detailed lnie with the com immune cells, in a manner b that we did not expect – admitted Jason Yang of the Broad Institute. – This is of great importance when pr You predict how a drug might work in tional humans or in s infections – added.
Syndrome ł scientc conducted studies on mice infected with E bacteria. coli. The rodents were given a popular antibiotic called ciprofloxacin at doses equivalent to those received by humans. By analyzing the biochemical changes in the animals, the researchers discovered a change in the metabolite’s – are compounds produced by the com rks that are the product of chemical transformations occurring in the body. They acted directly on the tissues of mice by increasing resistance E. coli to ciprofloxacin.
Moreover, by reducing respiratory activity in the com mice’s immune systems, exposure to antibiotics reduced the immune system’s ability to fight bacteria E. coli. Macrophages – com E glycemic rki, which re they participate in the body’s defense mechanisms, they become less effective at killing bacteria.
– Og lnally, antibiotics are assumed to have a significant effect on com bacterial cells, but seem to induce also reactions in bacterial com rks of mammals – said study leader James Collins of the Broad Institute. – Drugs cause changes that re actually detrimental to the therapeutic effort. They reduce the sensitivity of bacteria to antibiotics, and the drugs themselves reduce the ability of the com immune requriements to function properly – added.
All this means that antibiotics may have a deeper effect on chemical processes in the cell rks than we previously thought. This, in turn, can have a major impact on the effectiveness of therapy.
However, if the researchers succeeded in understanding why this happens, it could lead, to inhibit the growing resistance of bacteria to antibiotics. An also the question of how far antibiotics can limit the capabilities of the immune system. The researchers will now conduct tests on other animals and with other antibiotics. It also needs to be determined whether the lesions, which re observed in mice, also take place in humans. So far, we only have data on one infection and one antibiotic.
– We need to conduct additional animal studies in a wider range of conditions with a wider range of antibiotics in and potentially measure metabolites in patients in the treated – admitted Collins.